Mixon finished the day with 22 carries for 153 yards and four rushing touchdowns, to go with four catches for 58 yards and another score. He had an opportunity for a sixth touchdown, but quarterback Joe Burrow kept it himself for a 1-yard score.

Just two of Mixon’s five touchdowns were for more than 3 yards. They TDs, in order (score after the touchdowns and PATs in parentheses):

2-yard touchdown run (7-0, Cincinnati) 3-yard touchdown run (21-0, Cincinnati) 1-yard touchdown run (28-0, Cincinnati) 12-yard touchdown catch (35-0, Cincinnati) 14-yard touchdown run (42-7, Cincinnati)

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Mixon ran his way into the NFL history book with his performance. Here are each of his key highlights from the outing:

Where does Mixon’s day rank among the most for single-game touchdowns in NFL history? The Sporting News has that answer and more:

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Most touchdowns in a game in NFL history

Mixon on Sunday became the 17th player in NFL history to score five or more non-passing touchdowns in a game and the first since the Colts’ Jonathan Taylor in 2021. Mixon now owns the Bengals’ franchise record for touchdowns in a game, passing Marvin Jones’ four on Oct. 17, 2013, vs. the Jets.

Mixon is in a 14-way tie for fourth-most touchdowns in a game, trailing Alvin Kamara, Gale Sayers and Dub Jones’ six-touchdown games in 2020, 1965 and 1951, respectively. Former Seahawks running back Shaun Alexander holds the record for most touchdowns in a half, with five.

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Mosts fantasy points in a game

Mixon also had a fantastic fantasy outing. He produced the eighth-most fantasy points in NFL history, per StatMuse. He now fifth all time among running backs and second overall in 2022.